Radboud University Medical Center Nijmegen is one of the leading academic communities in the Netherlands.
The Research Laboratory of the Department of Rheumatology is located in the NCMLS, a research facility of the University of Nijmegen, which is devoted to biomedical research.
The research laboratory of experimental Rheumatology (around 30 people) has a consolidated experience on the study and analysis of animal models of rheumatic diseases with emphasis on rheumatoid arthritis and osteoarthritis.
We are the main developer of murine models of seronegative arthritis and techniques to monitor cartilage/bone destruction using histology. In WP 1 we will analyse the role of S100-DAMPs in cartilage/bone destruction in various mouse models of seronegative arthritis. In WP2 we will image S100-DAMPs in inflamed joints and couple this to metalloproteinase-mediated cartilage destruction. In WP3, we will analyse serum concentrations of S100-DAMPs in mouse models of seronegative