A5.13 Serum levels of S100A8/A9 complex and corticosterone correlate to synovial inflammation and cartilage/bone damage in IL-1RA-/-MICE, a model system for seronegative arthritis
In seronegative arthritis high levels of the alarmins S100A8 and S100A9 are measured in serum. These alarmins are released by activated macrophages and can mediate cartilage and bone destruction. Additionally, glucocorticoids have been implicated to stimulate S100A8 and S100A9 synthesis. The aim of this study is to identify serum S100A8/A9 complex as a potential biomarker for joint destruction in seronegative arthritis using IL-1Ra-/- mice as an experimental model and whether serum S100A8/A9 levels are associated with serum corticosterone (CORT) levels.